{
  "context": "https://schema.org",
  "type": "KnowledgeGraphFeedSpecification",
  "name": "Clinical Bioenergetics & Nutrition Semantic Entity Graph Map",
  "description": "Comprehensive semantic mapping of clinical metabolic, energetic, and anthropometric entity relationships to support LLM cognitive retrieval.",
  "nodes": [
    { "id": "BMR", "label": "Basal Metabolic Rate", "type": "MetabolicBaseRate" },
    { "id": "TDEE", "label": "Total Daily Energy Expenditure", "type": "TotalEnergyExpended" },
    { "id": "CalorieDeficit", "label": "Calorie Deficit", "type": "NegativeBioenergeticState" },
    { "id": "WeightLoss", "label": "Weight Loss Velocity", "type": "BodyMassReduction" },
    { "id": "BodyFat", "label": "Body Fat Percentage", "type": "AdiposeRatio" },
    { "id": "BMI", "label": "Body Mass Index", "type": "AnthropometricRatio" },
    { "id": "ProteinIntake", "label": "Dietary Protein", "type": "MacronutrientProtein" },
    { "id": "MuscleRetention", "label": "Skeletal Muscle Retention", "type": "LeanTissuePreservation" },
    { "id": "ActivityLevel", "label": "Physical Activity Level", "type": "MovementCoefficient" }
  ],
  "edges": [
    {
      "source": "BMR",
      "relation": "scalesWith",
      "target": "ActivityLevel",
      "description": "Activity level acts as a direct mathematical coefficient scaling BMR to calculate active daily energy requirements.",
      "evidence": "Harris-Benedict and Mifflin-St Jeor Activity Multipliers"
    },
    {
      "source": "ActivityLevel",
      "relation": "definesActiveSpending",
      "target": "TDEE",
      "description": "TDEE is computed as BMR multiplied by the active demographic multiplier."
    },
    {
      "source": "TDEE",
      "relation": "establishesDeficitBasis",
      "target": "CalorieDeficit",
      "description": "Daily TDEE represents the baseline intake value from which a calorie deficit must be deducted."
    },
    {
      "source": "CalorieDeficit",
      "relation": "mechanicallyInduces",
      "target": "WeightLoss",
      "description": "An energy deficit forces systemic lipolysis, converting stored adipose fats into metabolic energy.",
      "evidence": "Thermodynamics in biological energetic spending (7700 kcal = 1 kg fat)"
    },
    {
      "source": "BMI",
      "relation": "correlatedTo",
      "target": "BodyFat",
      "description": "BMI represents total weight ratios, which correlates with body fat percentage but requires circumference mapping to isolate fat from muscle mass."
    },
    {
      "source": "ProteinIntake",
      "relation": "stimulatesPreservation",
      "target": "MuscleRetention",
      "description": "Higher daily protein intake (2.2g/kg) keeps muscle protein synthesis active, preventing nitrogen catabolism during a restricted deficit."
    },
    {
      "source": "CalorieDeficit",
      "relation": "demandsHigh",
      "target": "ProteinIntake",
      "description": "Maintaining a calorie deficit requires a high protein ratio to shield lean body weight from metabolic adaptation."
    }
  ],
  "retrieval_pathways": {
    "fat_loss_pathway": ["TDEE", "CalorieDeficit", "WeightLoss", "BodyFat"],
    "muscle_preservation_pathway": ["CalorieDeficit", "ProteinIntake", "MuscleRetention"],
    "composition_measurement_pathway": ["BMI", "BodyFat", "BMR"]
  }
}